Skip to main content
Blizard Institute - Faculty of Medicine and Dentistry
  1. Blizard Institute
  2. Research
  3. Centres
  4. Centre for Immunobiology
  5. Queen Mary and Barts Health Tuberculosis Centre
  6. Our Research
  7. Immune Reconstitution Inflammatory Syndrome (IRIS) and Paradoxical Upgrading Reactions

Immune Reconstitution Inflammatory Syndrome (IRIS) and Paradoxical Upgrading Reactions

This research theme addresses the need for better scientific understanding of risk factors for, and the pathogenesis of, paradoxical upgrading reactions (PUR) in HIV-uninfected people. Such understanding is a necessary first step to developing new tools to identify those at risk and develop interventions to prevent and treat this common complication of anti-TB therapy. This work builds on a longstanding program of research on pathogenesis and treatment of HIV-associated TB Immune Reconstitution Inflammatory Syndrome (TB-IRIS), led by Graeme Meintjes.

Outputs

  • Meintjes G, Stek C, Blumenthal L, Thienemann F, Schutz C, Buyze J, Ravinetto R, van Loen H, Nair A, Jackson A, Colebunders R, Maartens G, Wilkinson RJ, Lynen L, Pred ARTTT. Prednisone for the Prevention of Paradoxical Tuberculosis-Associated IRIS. N Engl J Med. 2018;379(20):1915-25.
  • Meintjes G, Wilkinson KA, Rangaka MX, Skolimowska K, van Veen K, Abrahams M, Seldon R, Pepper DJ, Rebe K, Mouton P, van Cutsem G, Nicol MP, Maartens G, Wilkinson RJ. Type 1 helper T cells and FoxP3-positive T cells in HIV-tuberculosis-associated immune reconstitution inflammatory syndrome. Am J Respir Crit Care Med. 2008;178(10):1083-9.
  • Meintjes G, Wilkinson RJ, Morroni C, Pepper DJ, Rebe K, Rangaka MX, Oni T, Maartens G. Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome. AIDS. 2010;24(15):2381-90.
  • Meintjes G, Lawn SD, Scano F, Maartens G, French MA, Worodria W, Elliott JH, Murdoch D, Wilkinson RJ, Seyler C, John L, van der Loeff MS, Reiss P, Lynen L, Janoff EN, Gilks C, Colebunders R, International Network for the Study of HIVaI. Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. Lancet Infect Dis. 2008;8(8):516-23.
  • Tadokera R, Meintjes G, Skolimowska KH, Wilkinson KA, Matthews K, Seldon R, Chegou NN, Maartens G, Rangaka MX, Rebe K, Walzl G, Wilkinson RJ. Hypercytokinaemia accompanies HIV-tuberculosis immune reconstitution inflammatory syndrome. Eur Respir J.37(5):1248-59.

People

Back to top