Resistance to M. tuberculosis infection
A significant proportion of individuals who are heavily exposed to infectious tuberculosis patients remain unsensitised to M. tuberculosis antigens, suggesting that they may be able to resist infection. We are studying this phenotype in tuberculosis household contacts in Indonesia, aiming to identify immunological, metabolic and genetic correlates of protection against M. tuberculosis infection. Future work will incorporate molecular microbial blood biomarkers of M. tuberculosis infection to refine the ‘resister’ phenotype.
Outputs
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