Profile
Project Title: Single-molecule dissection of force-transmitting kinetochore-microtubule interface
Summary: My project is focused on understanding the molecular and mechanical mechanisms by which oligomers of Ndc80 and Dam1 complexes assemble at microtubule ends, and transmit microtubule-generated forces to chromosomes in budding yeast. Our approach is based on in vitro reconstitution of these molecular interactions using purified proteins. Dissecting these molecular mechanisms in detail is crucial to understand cell division in healthy and pathological scenarios, with latter including various cancers.
Supervisor: