Skip to main content
The William Harvey Research Institute - Faculty of Medicine and Dentistry

Breadcrumb

  1. WHRI
  2. Clinical Activities
  3. Barts Cardiovascular Clinical Trials Unit (CVCTU)
  4. CVCTU Trials Portfolio
  5. Continuum L

Continuum L

Full Title: A single-centre study comparing a continuous non-invasive lactate sensor measurement to standard invasive measurements of venous and arterial lactate in patients undergoing elective coronary artery bypass graft surgery +/- valve surgery.

Short Title: Continuum L

Sponsor: Queen Mary University of London

Funder: Barts Biomedical Research Centre

Chief Investigator: Prof Anthony Mathur, Professor of Cardiology, Queen Mary University of London & Co-Director for Cardiovascular Research, Barts Health NHS Trust

Co-Investigators: Prof Amrita Ahluwalia, Professor of Vascular Pharmacology, Dean for Research, Queen Mary University of London & Director of Barts CVCTU

Contact: whri-brc-cvctu@qmul.ac.uk

Registration: https://www.clinicaltrials.gov/study/NCT06597253

Study Design: A single-centre study investigating the relationship between a non-invasive continuous lactate sensor and standard blood lactate measurements in patients undergoing routine coronary artery bypass surgery (CABG) and/ or valve replacement surgery

Objectives:

  • Assess the correlation between non-invasive continuous lactate monitoring and standard venous/arterial blood lactate measurements
  • Evaluate the relationship between lactate sensor data and venous troponin measurements.
  • Assess the safety of the non-invasive lactate sensor

Number of Participants: Up to 76, with recruitment stopping after 20 participants with complete data

Device Used: NemCLM (Nemaura Pharma Ltd BEAT™ platform with a lactate sensor)

Study Duration: Approximately 9 months

Location: St. Bartholomew’s Hospital, Barts Health NHS Trust

Summary: Patients undergoing heart surgery require close monitoring to assess how well their bodies are coping with the procedure. One key indicator is lactate, a substance in the blood that can signal oxygen deprivation or metabolic stress. Currently, lactate levels are measured through repeated blood tests, which can be inconvenient and uncomfortable for patients.

The Continuum L Study is testing a wearable device that continuously tracks lactate levels without the need for invasive blood samples. By sticking to the skin, this device could provide real-time data on a patient’s condition, helping doctors detect potential complications sooner and adjust treatments more quickly.

The study aims to determine how accurately this new non-invasive sensor compares to traditional blood tests. If successful, it could revolutionise post-surgical care, reducing the need for repeated needle-based tests and providing a more comfortable and efficient monitoring system. Over time, this technology could be integrated into everyday medical practice, improving care for thousands of heart patients. In the future, the data from this new device will be used to train computer algorithms to provide quick responses that could help manage a patient’s condition, improving future medical care.

Back to top