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Continuum LINT

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Full Title: A single-centre study comparing continuous interstitial fluid lactate detection (as measured by change in current) to standard measurements of change in venous and arterial lactate in patients undergoing elective coronary artery bypass graft surgery and/or valve replacement

Short Title: Continuum LINT

Sponsor: Queen Mary University of London

Funders: Abbott Diabetes Care Ltd. & Queen Mary University of London

Chief Investigator: Prof Anthony Mathur, Professor of Cardiology, Queen Mary University of London & Co-Director for Cardiovascular Research, Barts Health NHS Trust

Co-Investigator: Prof Amrita Ahluwalia, Professor of Vascular Pharmacology, Dean for Research, Queen Mary University of London & Director of Barts CVCTU

Contact: whri-brc-cvctu@qmul.ac.uk 

Study Design: A single-centre study evaluating a continuous interstitial fluid lactate detection device compared to standard venous/arterial lactate measurements in patients undergoing elective coronary artery bypass graft surgery and/or valve replacement.

Objectives:

  • Assess how interstitial fluid lactate measurements correlate with venous and arterial lactate levels
  • Evaluate the relationship between lactate sensor data and venous troponin measurements
  • Evaluate device functionality for up to 48 hours post-surgery
  • Assess the safety of the non-invasive lactate sensor

Number of Participants: Up to 190 participants identified, with recruitment stopping after 50 participants with complete samples, aiming for sex balance

Device Used: Abbott Continuous Lactate Monitoring System, Investigational device by Abbott Diabetes Care Ltd.

Study Duration: Estimated 9 months

Location: St. Bartholomew’s Hospital, Barts Health NHS Trust

Summary: After heart surgery, patients need careful monitoring to ensure their recovery is progressing well. One way that doctors check this is by measuring lactate levels, which can indicate how well the body is using oxygen and whether the heart is under stress. However, current monitoring relies on frequent blood tests, which can be uncomfortable and only provide a snapshot at a single point in time.

The Continuum LINT Study is exploring a new way to measure lactate continuously and relatively non-invasively. By using a small wearable sensor, the study aims to determine if this technology can accurately track changes in lactate levels over time. This could allow doctors to monitor patients more effectively, detecting potential issues earlier and reducing the need for repeated blood samples.

This research is part of a broader effort to develop digital health solutions that provide real-time, personalised monitoring for patients. If the device proves effective, it could be used in hospitals to enhance post-surgical care, allowing for faster intervention when needed and improving patient outcomes.

Ultimately, this study could help pave the way for less invasive and more efficient monitoring methods in hospitals, benefiting both patients and healthcare providers.

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