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The William Harvey Research Institute - Faculty of Medicine and Dentistry

Professor Morris Brown, FRS, FMedSci

Morris

Professor of Endocrine Hypertension

Centre: Clinical Pharmacology and Precision Medicine

Email: morris.brown@qmul.ac.uk
Telephone: +44(0) 20 7882 3901

Profile

ORCID iD: 0000-0001-8409-1082

Formerly, Professor of Clinical Pharmacology, University of Cambridge 1985-2016

1999    Fellowship of Academy of Medical Sciences
2002    Lilly Prize, British Pharmacological Society
2003    Hospital Doctor of the Year 2003 – winner for Cardiovascular Medicine Section and overall winner
2005    Walter Somerville Medal, British Cardiac Society
2014    Pickering Lecturer, British Hypertension Society
2016    Royal College of Physicians/Lancet Research Award (for outstanding research contributing to excellent patient care’)
2018    International Society of Hypertension's Robert Tigerstedt Lifetime Achievement Award
2024    Endocrine Society’s Aurbach Award for Outstanding Translational Research
2025    Fellowship of the Royal Society

Research

Group members

  • Co-Supervisor: Prof Will Drake
  • Dr Elena Azizan, Visiting Lecturer
  • Dr Xilin Wu, Dr Emily Goodchild, Dr Kate Laycock (Academic Clinical Lecturers)
  • Dr Jessica Kearney, Dr Yun-ni-Lee, Dr Antoine Pineau-Mitchell (Clinical PhD Fellows)
  • Aklima Khatun, Research Co-ordinator
  • Denise Grant, Administrator

Summary 

I have studied causes and treatment of Hypertension since 1977, with concentration since moving to QMUL on Primary Aldosteronism. Principal discoveries:

  • AB/CD rule for the treatment of Hypertension (1999)
  • Two types of aldosterone-producing adenomas, and several gain-of-function somatic mutations (2013, 2021, 2023)
  • Aldosterone synthase inhibitors for hypertension and PA (2017, 2023, 2025)
  • Use of spironolactone for resistant hypertension (PATHWAY trials, 2015)
  • Molecular imaging for Primary Aldosteronism (2012, 2023)
  • Targeted thermal therapy (TTT) for aldosterone-producing adenomas (2025)

Please see https://royalsociety.org/people/morris-brown-37332/ for short summary.

Collaborators

Internal

  • Prof William Drake
  • Dr David Collier
  • Dr Chaz Mein
  • Ms Eva Wozniak
  • Dr Claudia Cabrera

External

The WAVE Investigators:

  • Dr Maria-Christina Zennaro, Inserm, Paris
  • Dr Celso Gomez Sanchez, University of Mississipi
  • Dr William Rainey, University of Michigan 

News

Society Roles and Public Engagement

  • Special Advisor to the Parliamentary Committee on Medical Training 2007-2008, following multiple letters in The Times, Lancet and BMJ, and Leadership of the ginger group, Fidelio
  • Advisory Board, International Patients Organization - www.primaryaldosteronism.org.
  • I have appeared on Radio 4 Inside Health, together with named patients, to raise awareness about Primary Aldosteronism and Hypertension - Link 1, Link 2.
  • I participated, with patients, in several articles, arranged by BHF about funded adrenal and hypertension research, e.g. Daily Mail and Reader’s Digest.

 

Teaching

My research group, co-supervised by Prof Will Drake, consists of 3-4 clinical PhD Fellows, usually trainees in Endocrinology, and 3 NIHR academic Clinical Lecturers (former PhD Fellows).

I also lecture on several Masters courses.



Disclosures

None

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