Professor Philip Eaton

Profile

Philip Eaton gained a BSc in Biochemistry from Queen Mary College, University of London in 1989 before completing his PhD studies at the University of Sussex. After post-doctoral work at the Institute of Psychiatry, he joined the Department of Cardiovascular Research at the Rayne Institute, St Thomas’ Hospital in 1995. He remained there for nearly 24 years within the School of Cardiovascular Medicine & Sciences at King’s College London. In 2019, he moved to the William Harvey Research Institute, Queen Mary University of London where he heads a group studying the molecular basis of redox sensing and signalling in the cardiovascular system.

Research

Group members

Dr. Rebecca Charles (BHF Intermediate Fellow): Dr. Hyunju Cho; Dr. Mariana Fernandez-Caggiano; Dr. Lorena Fernandez-Mosquera; Dr. Asvi Francois; Dr. Alisa Kamynina; Dr. Gundeep Kaur; Dr. Oleksandra Prysyazhna; Dr. Daniel Simoes De Jesus; Dr. Christopher Switzer

Summary 

Oxidants, which can be produced in cells and tissues, have been causatively implicated in the pathogenesis of most major diseases. Whilst this paradigm is still prevalent, and oxidants may indeed play important roles in the disease etiology, it is now understood that they can also serve as regulatory entities that are important for the maintenance of homeostasis during health and disease. Oxidants can be sensed and transduced into a biological event via their reaction with select cysteine thiol side chains on some proteins. Such reactions can result in oxidative post-translational modifications of proteins that in some cases alter their function to enable adaptation and homeostasis. By identifying thiol-based redox sensor proteins susceptible to oxidant-dependent alterations in structure and function, it is hoped a better understanding of the biological significance of these modifications during cardiovascular health and disease can be gained. Indeed, in some cases we have developed new electrophilic drugs that modify precise redox regulated cysteines for therapeutic purposes to combat cardiovascular disease. 

Publications

• de Jesus DS, Buffonge S, Abis G et al. (2024). Zinc-mediated inhibition of soluble epoxide hydrolase promotes pulmonary hypertension. nameOfConference

  
  

  DOI: 10.1016/j.freeradbiomed.2024.10.125

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/103127
• Knight H, Abis G, Kaur M et al. (2023). Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation. nameOfConference

  
  

  DOI: 10.1161/circresaha.122.321836

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92438
• Caggiano MF, Charles R, Prysyazhna O et al. (2023). UK-5099 does not inhibit the mitochondrial pyruvate carrier through irreversible adduction to cysteine 54 in MPC2. nameOfConference

  
  

  DOI: 10.1016/j.freeradbiomed.2023.10.148

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92439
• Heusch G, Andreadou I, Bell R et al. (2023). Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection. nameOfConference

  
  

  DOI: 10.1016/j.redox.2023.102894

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92458
• Rudyk O, Prysyazhna O, Eaton P (2023). BS17 Oxidation of protein kinase a regulatory subunit PKARIα alpha regulates vasodilation and blood pressure lowering. Basic Science

  
  

  DOI: 10.1136/heartjnl-2023-bcs.231

  
  

  QMRO: qmroHref
• Switzer CH, Kasamatsu S, Ihara H et al. (2023). SOD1 is an essential H2S detoxifying enzyme. nameOfConference

  
  

  DOI: 10.1073/pnas.2205044120

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92459
• Kamynina A, Guttzeit S, Eaton P et al. (2022). Blood pressure lowering by nitroxyl donor CXL-1020 is mediated by oxidation of Protein Kinase G I. nameOfConference

  
  

  DOI: 10.1016/j.yjmcc.2022.08.195

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92460
• Varadarajan S, Abdelsaid K, Boatwright H et al. (2022). Abstract 9930: Exercise-Induced ATP7A, A Cu Transporter for SOD3, Restores Endothelial Dysfunction in Type2 Diabetes via Cysteine Oxidation of Protein Kinase G. nameOfConference

  
  

  DOI: 10.1161/circ.146.suppl_1.9930

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92461
• Charles R, Fernandez-Caggiano M, Rudyk O et al. (2022). A novel inhibitor of soluble Epoxide Hydrolase that adducts C521 is cardioprotective. nameOfConference

  
  

  DOI: 10.1016/j.freeradbiomed.2022.10.090

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92464
• Francois AA, Yin X, Mayr M et al. (2022). Identification of Cardiac Proteins that Sense Oxidants by Intra-disulfide Formation. nameOfConference

  
  

  DOI: 10.1016/j.freeradbiomed.2022.10.099

  
  

  QMRO: qmroHref

News

• Olive oil and salad combined 'explain' Med diet success (BBC News), May 2014
• Olive oil on salad may save your life (The Telegraph), May 2014 
• New blood pressure control found (BBC News), August 2007
  Hopes rise for new generation of blood pressure drugs (The Guardian), August 2007