Dr Mohey Eldin El Shikh
Senior Lecturer, Education Lead (Centre for Experimental Medicine and Rheumatology), Lead (WHRI Work Experience Programme)
Centre: Experimental Medicine and Rheumatology
Email: m.elshikh@qmul.ac.ukTelephone: +44(0) 20 7882 8202
Research
In 2009 Dr El Shikh discovered the ability of immune-complex-loaded follicular dendritic cells (FDCs) to induce T cell-independent immunity to T cell-dependent antigens in responses co-stimulated with FDC-derived BAFF and C4bBP. He has recently described a novel pathway of antigen processing and presentation by FDCs to B cells in germinal centres that is potentially involved in autoreactive B cell activation, breach of B cell tolerance, and perpetuation of autoimmunity. His recent findings that B cell tolerance to self-TNF-alpha, -IgE, -ECDII, and -HEL can be broken in well verified models of tolerance by self-antigen presentation by FDCs support the hypothesis that presentation of self/neo-antigens to B cells by activated FDCs induces autoreactive GC formation, auto-Ab secretion, and perpetuation of B cell autoimmunity. He is currently dissecting the molecular mechanisms underpinning this hypothesis which will not only advance our understanding of the mechanisms involved in autoreactive B cell activation and breakage of tolerance but also potentially open up a novel therapeutic avenue by inducing high affinity self-regulated auto-Abs to target endogenous mediators of chronic autoimmune and hypersensitivity diseases like TNF-alpha IgE, and ECDII.
Publications
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Aly NAR, Rizk S, Enein AA et al. (publicationYear). The role of lymphoid tissue SPARC in the pathogenesis and response to treatment of multiple myeloma. nameOfConference
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Shikh MEME, Sayed RE, Aly NAR et al. (publicationYear). Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis. nameOfConference
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Elsayed R, Kurago Z, Cutler CW et al. (2020). Role of dendritic cell‐mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw. nameOfConference
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El Shikh MEM, El Sayed R, Nerviani A et al. (2019). Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis. nameOfConference
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Rivellese F, Mauro D, Nerviani A et al. (2018). Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production. nameOfConference
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Shikh ME, Sayed RE, Fossati-Jimack L et al. (2018). O001 Lymphoid tissue macrophages express peptidylarginine deiminase 2 and 4: new implications in citrullination and anti-citrulline antibodies production in autoimmune arthritis. Oral presentations
QMRO: qmroHref -
Altamimi A-MS, Alafeefy AM, Balode A et al. (2017). Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A. nameOfConference
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Lownik JC, Luker AJ, Damle SR et al. (2017). ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses. nameOfConference
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El Shikh MEM, El Sayed R, Pitzalis C (publicationYear). Isolation and Characterization of Mouse and Human Follicular Dendritic Cells.. nameOfConference
Sponsors
Collaborators
Internal
- Costantino Pitzalis (QMUL)
- Francesco Dell'Accio (QMUL)
- Michele Bombardieri (QMUL)
External
- John G. Tew, (School of Medicine, VA, USA)
- Daniel H. Conrad, (School of Medicine, VA, USA)
- Masoud H. Manjili, (School of Medicine, VA, USA)
- Harvey A. Schenkein, (VCU School of Dentistry)
- Christopher G. Mueller ,Immunologie et Chimie Therapeutiques)