Dr Suzanne Eldridge

Profile

Dr Suzanne Eldridge is a molecular biologist with a background in engineering whose main research interest is in the regeneration of musculoskeletal tissues. During her PhD she discovered the role of Agrin in cartilage homeostasis. Her predominant aim is to develop new therapeutic technologies which will either prevent cartilage breakdown or enhance cartilage repair, for use in disease (such as osteoarthritis) and following cartilage trauma.

Research

Group members

Aida Barawi (PhD student); Manasi Sayilakshmy (Technician); Zara Khan (PhD student)

Summary

Dr Eldridge is a molecular biologist with a background in engineering whose main research interest is in the regeneration of musculoskeletal tissues. During her PhD she discovered the role of Agrin in cartilage homeostasis. Her predominant aim is to develop new therapeutic technologies which will either prevent cartilage breakdown or enhance cartilage repair, for use in disease (such as osteoarthritis) and following cartilage trauma.

Opportunities in the group

Dr Eldridge has a range of projects available to students including:

• Short/long term undergraduate projects (either as part of a degree programme or independently)
• MSc projects
• PhD studentships (funded when possible) 

Please email Dr Eldridge at s.e.eldridge@qmul.ac.uk for more information.

Publications

• Caxaria S, Kouvatsos N, Eldridge SE et al. (2022). Disease modification and symptom relief in osteoarthritis using a mutated GCP-2/CXCL6 chemokine. nameOfConference

  
  

  DOI: 10.15252/emmm.202216218

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/82578
• Thorup A-S, Dell’Accio F, Eldridge SE (2023). A Mouse Model of Acute Cartilage Injury and Repair. nameOfConference

  
  

  DOI: 10.1007/978-1-0716-2839-3_24

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/82668
• Eldridge S, Barawi A, Thorup AS et al. (2022). AB0156 INTRA-ARTICULAR AGRIN PROVIDES DIRECT PAIN RELIEF IN OSTEOARTHRITIS AND CARTILAGE DEFECTS. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2022-eular.3483

  
  

  QMRO: qmroHref
• Thorup A-S, Wilson J, Strachan D et al. (2022). BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS, IN PART BY MODULATING YAP SIGNALLING. nameOfConference

  
  

  DOI: 10.1016/j.joca.2022.02.201

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/95161
• THORUP A, Caxaria S, Dell'Accio F et al. (2022). In vivo potency assay for the screening of bioactive molecules on cartilage formation. nameOfConference

  
  

  DOI: 10.1038/s41684-022-00943-y

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/76951
• Eldridge S, Barawi A, Wang H et al. (2021). AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2021-eular.2584

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73100
• Thorup AS, Strachan D, Caxaria S et al. (2021). OP0200 BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2021-eular.2358

  
  

  QMRO: qmroHref
• Thomas B, Eldridge S, Nosrati B et al. (2021). WNT3A-loaded exosomes enable cartilage repair. nameOfConference

  
  

  DOI: 10.1002/jev2.12088

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/68377
• Nalesso G, Thorup A-S, Eldridge SE et al. (publicationYear). Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis. nameOfConference

  
  

  DOI: 10.1038/s41598-021-82067-w

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/70801
• Thorup A-S, Strachan D, Caxaria S et al. (2020). ROR2 blockade as a therapy for osteoarthritis. nameOfConference

  
  

  DOI: 10.1126/scitranslmed.aax3063

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67172

News

• Doubling down on osteoarthritis (Nature), October 2020
• New molecule repairs cartilage and relieves symptoms of osteoarthritis (Queen Mary University of London), September 2020
• BBC Radio 5 Live interview (14:38), (BBC) September 2020
• Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis (Science Translational Medicine), September 2020
• ROR2 blockade as a therapy for osteoarthritis (Science Translational Medicine), September 2020
• Preventing the pain of osteoarthritis - do molecules and proteins hold the answers? (Centre for Sport, Exercise & Osteoarthritis Research / Versus Arthritis), August 2017