Dr Dan Jones
Reader in Interventional Cardiology Clinical Trials
Centre: Cardiovascular Medicine and Devices
Email: daniel.jones@qmul.ac.ukTwitter: @Bhcintervention
Profile
Daniel Jones is a Reader based within Barts Cardiovascular Clinical Trials Unit (CVCTU) and an Interventional Cardiologist at Barts Heart Centre. He completed his medical degree (MBBS) at St Georges Hospital Medical School in 2004, which involved an Intercalated BSc (2:1) in basic medical science awarded in 2001. He completed his PhD funded through an NIHR Doctoral Research Fellowship in 2015 at Queen Mary University of London based on the Investigation of the effect of nitrite in the management and treatment of myocardial infarction’ performed with Professors Anthony Mathur and Amrita Ahluwalia.
His primary research interests are based around translational interventional clinical trials, having completing an MSc in clinical trial design. Other interests include the treatment of reperfusion injury following myocardial infarction, novel therapies for myocardial regeneration, the cost-effectiveness of cardiovascular therapies and the study of outcomes after percutaneous coronary intervention.
Awards
- 2023 SCCT Clinical Trials and Registry Award: BYPASS-CTCA Sub-study
- 2022 HSJ Award Acute Sector Intervention: Barts AMI Discharge Pathway
- 2021 BMJ Award: Stroke and Cardiovascular Team of The Year: “Barts Early Discharge after AMI”
- 2019 Young Leadership Award – CRT 2019
- 2017 Young Investigator Award ‘Outcome after PCI’ at the ESC Annual Congress, Barcelona
2017 Award for Academic Achievement 150th Anniversary Prize Awarded by University of London - 2015 Young Investigator Award 6th International Meeting on the Role of Nitrite and Nitrate in Physiology, Pathophysiology, and Therapeutics
Research
Group members
- Barts Interventional Cardiology Research Department: Prof Anthony Mathur, Prof Andreas Baumbach, Mervyn Andiapen, Ruth Bowles, Lucinda Wynne
- Vascular Pharmacology Group: Prof Amrita Ahluwalia (Head), Vikas Kapil (Senior Lecturer), Dr Krishnaraj Rathod (Senior Lecturer)
- Barts Cardiovascular CTU: Prof Amrita Ahluwalia (Director), Ms Jessica Adams, (Manager), Dr Ajay Gupta (Senior Lecturer)
Summary
Dr Jones's research focus is around improving outcomes for patients with coronary artery disease specifically those undergoing invasive coronary procedures. There is a strong focus on translational cardiovascular research, with his main interest being taking the potential benefits of nitric oxide from bench to bedside in the treatment of cardiovascular disease and the use of CTCA in improving outcomes in the post-bypass patient.
Inorganic Nitrite/Nitrate in Cardiovascular Disease: A major research focus is the use of inorganic nitrate/nitrite and cardiovascular outcomes. In 2015 as part of his PhD he helped demonstrate that intracoronary nitrite reduces infarct size and improve outcomes after primary angioplasty for myocardial infarction in a first in man phase II study.
On-going research focuses on Inorganic nitrate for prevention of contrast nephropathy after percutaneous coronary intervention (PCI) - https://heartresearch.org.uk/grants/coronary-angiography
CT Coronary Angiography for improving outcomes in patients post CABG: Dr Jones was the PI of the recently completed BYPASS-CTCA study assessing the routine use of upfront CTCA prior to invasive angiography to improve procedural metrics, outcomes and patient satisfaction. This was presented at TCT in 2022 and published in Circulation, and the subject of an award from SCCT in 2023.
Clinical Trials: Focus of clinical trials in interventional cardiology alongside Prof Anthony Mathur and Prof Andreas Baumbach
Current areas include:
- Stem Cell Therapy for treatment of Heart Failure/Refractory Angina
- Improving revascularisation in the post-surgical patient
- Optimisation of Outcomes post MI (DAPA-MI, LIBREXIA-ACS, COMPLETE-2_
- Risk-stratification in MI with normal coronary arteries (MINOCA)
Publications
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Kelham M, Beirne A-M, Rathod KS et al. (2024). CTCA Prior to Invasive Coronary Angiography in Patients With Previous Bypass Surgery: Patient-Related Outcomes, Imaging Resource Utilization, and Cardiac Events at 3 Years From the BYPASS-CTCA Trial. nameOfConference
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Erlinge D, James S, Deanfield J et al. (2024). Impact of dapagliflozin on cardiometabolic outcomes after myocardial infarction according to baseline left ventricular ejection fraction: a DAPA-MI substudy. nameOfConference
QMRO: qmroHref -
Sayers M, Rathod K, Akhtar M et al. (2024). Prognostic significance of coexistent coronary artery disease in patients undergoing transcatheter aortic valve implantation for aortic stenosis. nameOfConference
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Rathod KS, Mathur A, Shabbir A et al. (2024). The NITRATE-OCT study-inorganic nitrate reduces in-stent restenosis in patients with stable coronary artery disease: a double-blind, randomised controlled trial. nameOfConference
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Leikas AJ, Hartikainen JEK, Kastrup J et al. (2024). Clinical development and proof of principle testing of new regenerative vascular endothelial growth factor-D therapy for refractory angina: rationale and design of the phase 2 ReGenHeart trial. nameOfConference
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Kelham M, Beirne A-M, Rathod KS et al. (2024). OP1 The use of computed tomography coronary angiography as a gatekeeper to predict the need for invasive coronary angiography in patients with previous CABG presenting with acute coronary syndromes. OP1 The use of computed tomography coronary angiography as a gatekeeper to predict the need for invasive coronary angiography in patients with previous CABG presenting with acute coronary syndromes
QMRO: qmroHref -
Vyas R, Kelham M, Beirne A-M et al. (2024). OP5 Diagnostic accuracy of CTCA for graft and native disease assessment in patients with previous CABG: insights from the BYPASS-CTCA trial. OP5 Diagnostic accuracy of CTCA for graft and native disease assessment in patients with previous CABG: insights from the BYPASS-CTCA trial
QMRO: qmroHref -
McFarlane R, Jones DA, Berry C (2024). CCTA to Routinely Guide Invasive Management in Patients With CABG: Over-Testing or Essential?. nameOfConference
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Kelham M, Mathur A, Jones DA (2024). Response to Letter Regarding Article “The effect of CTCA guided selective invasive graft assessment on coronary angiographic parameters and outcomes: Insights from the BYPASS-CTCA trial”. nameOfConference
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Kelham M, Vyas R, Rameseshan R et al. (2024). Routine Invasive Versus Conservative Management of Non-ST Elevation Acute Coronary Syndromes in Patients With Previous Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis of Randomised Clinical Trials. nameOfConference
Collaborators
Internal
- Dr Andrew Wragg
- Dr Malcolm Finlay
External
- Prof Colin Berry
- Prof Vijay Kunadian
- Dr Thomas Keeble
News
- Dietary Nitrate Dramatically Cuts Contrast-Induced Nephropathy (tctmd), August 2023
- Inorganic nitrate improves safety of coronary angiography in patients at renal injury risk (European Society of Cardiology), August 2023
- CCTA in Patients With Prior CABG Cuts Complications of Invasive Angio: BYPASS-CTCA (tctmd), September 2022
Teaching
Dr Jones has a strong commitment to teaching and training within the university. He is involved in teaching medical students on the MBBS course and PA students on the Physician Associate MSc course. He also regularly mentors students for SSC1 and SSC4 on the QMUL undergraduate syllabus and supervisors QMUL medical students for summer elective modules (Rod Flower Scholarship (per year last 3 years).
MD/PhD Supervision: To date, Dr Jones has supervised 1 student to the completion of a PhD as 2nd supervisor and is currently the primary supervisor for 3 ongoing PhD/MD students.
He also runs the Cardiology Boot Camp for Physician Associates and Allied Health Professionals through QMUL and the CVDHub and contributes to regular short courses and teaching through the CVDHub.
Disclosures
No disclosures.