Dr Suchita Nadkarni

Profile

ORCID iD: 0000-0002-4549-3983

Suchita obtained her BSc in Biomedical Science at King’s College London. She then went on to obtain her PhD at University College London, under the supervision of Profs Michael Ehrenstein and Claudia Mauri, where she investigated the role of regulatory T-cells in anti-TNF-treated rheumatoid arthritis patients. Following a brief post-doc in New York, Suchita left lab-based research for a year to work as a Senior Science Adviser to the Government. In 2009, she then returned to lab research, undertaking post-doc project with Prof Mauro Perretti at the WHRI looking into the role of neutrophils in patients with Giant Cell Arteritis. It was during this time that Suchita developed her interests in neutrophils, combining it with her background in T-cell immunology.

In 2013 Suchita joined Prof Federica Marelli-Berg’s group, where she developed her niche investigating the importance of neutrophil-T cell interactions during pregnancy. In 2017 Suchita was awarded a 5-year intermediate research fellowship from the British Heart Foundation.

Research

Group members

Dr Eleanor Ward (Postdoctoral Researcher); Dr Alice Christensen (Clinical Fellow); Ms Serena Bert (PhD student)

Summary 

Suchita’s work focuses on the role of the maternal immune system in shaping pregnancy outcomes. Suchita is specifically interested in how maternal neutrophils can influence T-cell responses and how such interactions can regulate placental development (see image) and her main disease area of interest is pre-eclampsia In addition to their roles in placental development, Suchita is also interested in how neutrophil-T cell interactions can influence maternal cardiovascular responses during pregnancy and fetal development.

The Placenta Rainbow  - Wellcome Image Award 2017 and National Geographic 2018

Using wide-field confocal scanning microscopy, The Placenta Rainbow, depicts 9 different mouse placentas that have been individually imaged and arranged in PhotoShop.  Each placenta derives from a distinct mouse pregnancy in which the mother’s immune system has been manipulated to assess the architecture of the placentas. Following extraction, the placentas are labelled with different coloured antibodies that bind to specific proteins.  The varying colours denotes specific structures within the placenta and allows us to assess whether manipulation of the mother’s immune system affects development of the placenta.  Such assessments could help identify targets for complications arising in human pregnancies.

Publications

• Artinger K, Russo S, Gutjahr J et al. (2023). #4574 ATYPICAL CHEMOKINE RECEPTOR 4 IS EXPRESSED IN GLOMERULAR PARIETAL EPITHELIAL CELLS AND MITIGATES THE SEVERITY OF EXPERIMENTAL GLOMERULONEPHRITIS. nameOfConference

  
  

  DOI: 10.1093/ndt/gfad063c_4574

  
  

  QMRO: qmroHref
• Ward EJ, Bert S, Fanti S et al. (2023). Placental Inflammation Leads to Abnormal Embryonic Heart Development. nameOfConference

  
  

  DOI: 10.1161/circulationaha.122.061934

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/83242
• Bert S, Nadkarni S, Perretti M (2023). Neutrophil‐T cell crosstalk and the control of the host inflammatory response. nameOfConference

  
  

  DOI: 10.1111/imr.13162

  
  

  QMRO: qmroHref
• Coe D, Poobalasingam T, Fu H et al. (2022). Loss of hydrogen voltage-gated channel-1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T-cells. nameOfConference

  
  

  DOI: 10.1172/jci.insight.147814

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/78950
• Volpato LK, Nadkarni S, Horevicz VV et al. (2022). Contribution of plasma, placental, inflammatory and pro-resolving mediators in labor induction. nameOfConference

  
  

  DOI: 10.1016/j.placenta.2022.03.014

  
  

  QMRO: qmroHref
• Marino S (2021). Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC‐derived neural stem cells in glioblastoma.. nameOfConference

  
  

  DOI: 10.1038/s41467-021-26297-6

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/74928
• Jangani M, Vuononvirta J, Yamani L et al. (2022). Loss of mTORC2-induced metabolic reprogramming in monocytes uncouples migration and maturation from production of proinflammatory mediators. nameOfConference

  
  

  DOI: 10.1002/jlb.1a0920-588r

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/77361
• Man F, Nadkarni S, Kanabar V et al. (2021). A peptide derived from chaperonin 60.1, IRL201104, inhibits LPS-induced acute lung inflammation. nameOfConference

  
  

  DOI: 10.1152/ajplung.00155.2021

  
  

  QMRO: qmroHref
• Bert S, Ward EJ, Nadkarni S (2021). Neutrophils in pregnancy: New insights into innate and adaptive immune regulation. nameOfConference

  
  

  DOI: 10.1111/imm.13392

  
  

  QMRO: qmroHref
• Jacob J, Nadkarni S, Volpe A et al. (2021). Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment. nameOfConference

  
  

  DOI: 10.1016/j.omtm.2020.12.003

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74309

Collaborators

Internal

• Prof Federica Marelli-Berg (WHRI)

Clinical collaborators

• Dr Elena Greco
• Dr Stamatina Iliodromiti
• Prof Steve Thornton
• Dr Anna Herrey
• Dr Neha Sekhri

News

• The Placenta May Hold Clues to a Deadly Pregnancy Illness
  National Geographic, March 2018
  
  
• Wellcome image awards 2017
  Wellcome, March 2017
  
  
• The Wellcome image awards 2017: the shortlist of the years best science visions
  The Observer, March 2017