Dr Mathieu-Benoit Voisin
Senior Lecturer in Immunology
Centre: Microvascular Research
Email: m.b.voisin@qmul.ac.ukTelephone: +44(0) 20 7882 3909
Profile
ORCID iD: 0000-0003-3001-0894
Mathieu-Benoit Voisin graduated in 2000 from the University of Bordeaux II (France) in Biological Sciences with a specialisation in Immunology. He obtained his PhD from the University of Tours (France) in 2003 and conducted post-doctoral research at Imperial College London. In 2007, he relocated with Prof Nourshargh to the William Harvey Research Institute to investigate the mechanisms of leukocyte diapedesis through blood vessels, developing new imaging techniques to visualise the responses. His work lead him to receive the Werner Risau New Investigator Award in Vascular Biology in 2010. In 2012 he was the recipient of the prestigious Versus Arthritis Career Development Fellowship to establish his own independent research programme studying neutrophil migration and functions in the lymphatic & lymphoid system.
Since 2017, Dr Voisin is a Principal Investigator and Senior Lecturer in Immunology at the Centre for Microvascular Research.
Research
Group members
Researcher/Staff: Dr Jonathon Alexis Coates; Ms Julia Dielesen (PhD Student)
Summary
Neutrophils are key effectors of the innate immune response but can also contribute to the development of many acute inflammatory diseases. There is also evidence for neutrophil involvement in the regulation of the adaptive immunity and the pathogenesis of numerous chronic inflammatory conditions such as rheumatoid arthritis. The precise role of neutrophils in this autoimmune disorder is unclear and the focus of my research is to elucidate the mechanisms of neutrophil migration into lymphatic vessels and lymph nodes following antigen-induced arthritis and their role in the regulation of the acquired immunity. The main hypothesis is that neutrophil entry into lymphatic vessels plays an important role in the initiation of autoimmune diseases by changes in their phenotypes and their entry to the lymphatic vascular system. The project thus aims to characterize the mechanisms of neutrophil/lymphatic vessel interactions in vivo as analyzed by intravital confocal microscopy and the implications of this response to the development of arthritis. Collectively, the project will address a previously unexplored aspect of leukocyte biology and chronic disorders thus making a significant and novel contribution to the field of inflammation.
Publications
-
Rolas L, Stein M, Barkaway A et al. (2024). Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues. nameOfConference
-
Caxaria S, Bharde S, Fuller AM et al. (2023). Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia. nameOfConference
-
Joulia R, Guerrero-Fonseca IM, Girbl T et al. (publicationYear). Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A. nameOfConference
-
Iqbal AJ, Krautter F, Blacksell IA et al. (2022). Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner. nameOfConference
-
Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A et al. (2021). Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. nameOfConference
-
Barkaway A, Rolas L, Joulia R et al. (2021). Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. nameOfConference
-
Topping LM, Thomas BL, Rhys HI et al. (2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. nameOfConference
-
Owen-Woods C, Joulia R, Barkaway A et al. (2020). Local microvascular leakage promotes trafficking of activated neutrophils to remote organs. nameOfConference
DOI: 10.1172/JCI133661
-
Arokiasamy S, King R, Boulaghrasse H et al. (2019). Heparanase-dependent Remodelling of Initial Lymphatic Glycocalyx 1 Regulates Tissue-fluid Drainage during Acute Inflammation in vivo. nameOfConference
-
VOISIN M, leoni G, WOODFIN A et al. (2019). Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury. nameOfConference
DOI: 10.1002/path.5234
Sponsors
- British Heart Foundation
- William Harvey Research Foundation
- Versus Arthritis (Formerly Arthritis Research UK)
Collaborators
Internal
- Prof S. Nourshargh (WHRI)
- Prof C. Pitzalis (WHRI)
- Prof M. Perretti (WHRI)
- Dr P Longhi (WHRI)
- Prof A Nissim (WHRI)
- Prof F Marelli-Berg (WHRI)
- Dr M. Capasso (BCI)
- Dr Esther Castellano Sanchez (BCI)
External
- Prof Q. Sattentau (Oxford)
- Prof R Chambers (UCL)
- Prof J Greenwood (UCL)
- Prof J. Gutierrez (Costa Rica)
- Prof Ed Rainger (University of Birmingham)
News
- Dr. Mathieu-Benoit Voisin awarded Arthritis Research UK Fellowship (January 2012).
- Dr. Mathieu-Benoit Voisin awarded Young Investigator Award (Best oral presentation) at the international meeting of “Neutrophil in Immunity”, Quebec, Canada (June 2012).