Professor Magdi Yaqoob
Joint Head of Department
Centre: Translational Medicine and Therapeutics
Email: m.m.yaqoob@qmul.ac.ukTelephone: +44(0) 20 7882 2121
Profile
Magdi Yaqoob is Professor of Nephrology within Centre for Translational Medicine & Therapeutics at the William Harvey Research Institute (WHRI) and academic director of department of Renal Medicine and Transplantation at the Barts Health NHS Trust, UK. He graduated as one of the best graduates in Medicine (1982) from Dow Medical College, Karachi University, Pakistan. After general professional clinical training during which he obtained membership of the Royal College of Physician London (1985) he started specialist nephrology training in Liverpool, UK in 1987. He submitted his MD thesis on occupational factors in kidney disease in Liverpool University 1993. He obtained NIH fellowship to work as postdoctoral clinician/scientist under Prof Robert Schrier at Denver Colorado (194-1995). He joined the Royal London Hospital as consultant in 1996 and was awarded personal chair in Nephrology by QMUL in 2011. He received several awards (best European young investigator of the year 1992 and trainee investigator of the year by association of physicians USA, 1994).
Magdi Yaqoob is an internationally recognised expert in nephrology and transplant medicine in area of cardiovascular diseases of uraemia, renal anaemia, and renal bone disease, progression of chronic kidney disease and mediators of acute kidney injury.
Research
Nephrology and Transplant Medicine Research Group
We have a long-standing research interest in the pathophysiology and novel therapeutic strategies (preclinical and clinical) of:
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Ischaemia-reperfusion of the heart in uraemia and kidney (acute kidney injury, chronic kidney disease, renal fibrosis)
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Genetic factors determining the long-term outcomes of renal transplants
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Insulin resistance in CKD
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Autophagy and premature ageing in uraemia
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Molecular mechanisms of EPO resistance.
Over the years, we have identified a number of new therapeutic targets poly (ADP-ribose) polymerase (PARP), Hypoxiainducible factor stabilizers, calpain/caspases, acidosis, anti-inflammatory suppression of cytokine signalling, pleiotropic effects of erythropoietin their analogues, ischaemic preconditioning, sodium sensing in endothelial cells and galectins 1 & 3 in microcirculatory unit to name but a few. More recently as part of the NIHR-funded Barts-BRU, we have focused on the development of highly translational repositioning strategies, the efficacy of which is currently evaluated in patients with chronic kidney disease and transplant waiting list patient.
Publications
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Shah SN, Knausenberger TB-A, Pontifex MG et al. (2024). Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor. nameOfConference
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Randall D, Alsam A, Kieswich J et al. (2024). Oral dysbiosis initiates periodontal disease in experimental kidney disease. nameOfConference
DOI: 10.1093/ndt/gfae266
QMRO: qmroHref -
Young M, Miller JJJJ, Shattock MJ et al. (2024). Dual inhibition of SGLT 1 and 2 alleviates intracellular sodium overload in uraemic cardiomyopathy. nameOfConference
QMRO: qmroHref -
McGuigan K, Laurente G, Christie A et al. (publicationYear). Effectiveness of interventions for informal caregivers of people with end-stage chronic illness: a systematic review. nameOfConference
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Seet C, Clementoni L, Akhtar MR et al. (publicationYear). Assessing Patients beyond the Simple Optics of BMI: The Concomitant Role of Sarcopenia and BMI in Predicting Kidney Transplant Outcomes. nameOfConference
DOI: 10.3390/life14081036
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Chowdhury TA, Mukuba D, Casabar M et al. (2024). Management of diabetes in people with advanced chronic kidney disease. nameOfConference
DOI: 10.1111/dme.15402
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Fussner LA, Flores-Suárez LF, Cartin-Ceba R et al. (2024). Alveolar Hemorrhage in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Results of an International Randomized Controlled Trial (PEXIVAS).. nameOfConference
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Junek ML, Merkel PA, Vilayur E et al. (2024). Risk of Relapse of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in a Randomized Controlled Trial of Plasma Exchange and Glucocorticoids. nameOfConference
DOI: 10.1002/art.42843
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KASHEM TS, Rashid HU, Yaqoob M et al. (2024). WCN24-1827 TUBERCULOSIS –OBSERVATIONAL STUDY IN A NEPHROLOGY TERTIARY CARE CENTRE AT KIDNEY FOUNDATION HOSPITAL AND RESEARCH INSTITUTE, BANGLADESH. nameOfConference
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Jones DA, Beirne A-M, Kelham M et al. (2024). Inorganic nitrate benefits contrast-induced nephropathy after coronary angiography for acute coronary syndromes: the NITRATE-CIN trial. nameOfConference
Sponsors
Collaborators
Internal
- Prof Chris Thiemermann (WHRI)
- Prof Mauro Perretti (WHRI)
- Prof Amrita Ahluwalia (WHRI)
- Prof Chris Thiemermann (WHRI)
- Prof Roger Corder (WHRI)
- Prof Tim Warner (WHRI)
External
- Prof Anthony Cerami (University of Leiden, The Netherlands)
- Dr Massimo Collino (University of Turin, Italy)
- Prof Jonathan Sekl (Edinburgh University)
- Prof Derek Gilroy (UCH)
- Dr Andrew Wragg (Barthealth NHS UK)